MBD3 anticorps (AA 1-290)

N° du produit ABIN5027348

Cet anticorps anti-MBD3 est un anticorps Souris Monoclonal détectant MBD3 dans WB, IHC et FACS. Adapté pour Humain.

Aperçu rapide pour MBD3 anticorps (AA 1-290) (ABIN5027348)

Antigène: MBD3 (Methyl-CpG Binding Domain Protein 3 (MBD3))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MBD3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)

Clone: ABM14A8

Détail du produit anti-MBD3 anticorps

Épitope: AA 1-290

Purification: Protein G Chromatography

Immunogène: A partial length recombinant MBD3 protein (amino acids 1-290) was used as the immunogen for this antibody.

Isotype: IgG1 kappa

Information d'application

Indications d'application: WB: 2-4 μg/mL, IHC: 5 μg/mL, FACS: 0.5 μg/10^6 cells

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Détails sur MBD3

Antigène: MBD3 (Methyl-CpG Binding Domain Protein 3 (MBD3))

Autre désignation: MBD2/MBD3

Sujet: MBD2 is a subunit of the NuRD complex that is postulated to mediate gene repression via recruitment of the complex to methylated DNA. This protein binds around 1 kb downstream of the transcription start site of a subset of 400 CpG island promoters that are characterized by the presence of active histone marks, RNA polymerase II (Pol2) and low to medium gene expression levels and H3K36me3 deposition. Methylated MBD2 is involved in silencing methylated tumor suppressor genes as well as activation of pro-metastatic genes. MBD2 also plays a key role in regulating expression of a range of genes that are associated with optimal DC (Dendritic cells) activation and function.

Poids moléculaire: 32. 44 kDa

ID gène: 53615

UniProt: O95983

Pathways: Chromatin Binding